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The UltimaGral is a ‘through-the-wall’, high-shear mixer that offers the best option in terms of cleanliness, maintenance and explosion protection. The UltimaGral can be equipped with a ‘Movable Head’ to allow operators to lower the closed bowl to enable better accessibility and easy loading.
With bowl capacities of 10–1200 L (useful bowl content up to 2/3 of gross capacity), the UltimaGral range can cover all requirements after the formulation stage. From clinical batch production for scale-up trials to large-scale production for marketed products, scalability is key to the system’s success. The most important features of this design are the top-driven mixer and chopper, the optimized design to ensure easy cleaning & GMP compliance, and the through-the-wall installation of the larger machines.
Binder addition is one of the critical phases determining product quality within a wet granulation process. A range of binder addition systems are available to give the optimum binder liquid droplet size.
A range of control systems for maximum level of flexibility and functionality for process visualisation, automation and data recording are available, including torque control for end point determination.
PAT Integration, combining process monitoring using online analysers with solid process engineering principles and advanced process modelling techniques, enable processes to be actively controlled in order to compensate for minor input variations in raw materials and environment conditions so that the specifications for the final product will be closer to the ideal target.
The design of the UltimaGral ensures that lines and hoses for the utilities on the machine (water, electricity, hydraulics, etc.) are concealed in the machine encasement. This creates an uncluttered working space and avoids hoses being run to the machine within the process area.
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